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Table 1 Prevalence of single nucleotide polymorphism in Pfdhfr and Pfdhps per site

From: Trends in drug resistance codons in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Kenyan parasites from 2008 to 2012

  

DHFR prevalence per site

DHPS prevalence per site

 

CODON

16

50

51

59

108

164

S436A/F/H

437

540

581

613

  

% (n)

% (n)

% (n)

% (n)

% (n)

% (n)

% (n)

% (n)

% (n)

% (n)

% (n)

KDH

WILD

100 (266)

100 (289)

1.4 (4)

3.5 (10)

0.3 (1)

98.7 (302)

100 (256)

1.5 (4)

7.5 (21)

97.2 (273)

100 (284)

MUTANT

0 (0)

0 (0)

96.9 (279)

92.7 (267)

99.6 (296)

1 (3)

0 (0)

98.1 (264)

91.1 (256)

0.4 (1)

0 (0)

MIXED

0 (0)

0 (0)

1.7 (5)

3.8 (11)

0 (0)

0.3 (1)

0.4 (1)

0.4 (1)

1.4 (4)

2.5 (7)

0 (0)

KSI

WILD

100 (152)

100 (155)

1.3 (2)

11.0 (17)

0 (0)

98.1 (155)

100 (87)

1.1 (1)

9.9 (14)

96.7 (146)

100 (117)

MUTANT

0 (0)

0 (0)

96.9 (152)

82.5 (127)

100 (156)

1.32 (2)

0 (0)

97.9 (91)

89.4 (126)

2.0 (3)

0 (0)

MIXED

0 (0)

0 (0)

1.9 (3)

6.5 (10)

0 (0)

0.6 (1)

0 (0)

1.1 (1)

0.7 (1)

1.3 (2)

0 (0)

KCH

WILD

100 (93)

100 (93)

2.2 (2)

7.7 (6)

2.1 (2)

100 (93)

98.9 (89)

2.2 (2)

3.8 (4)

98.1 (102)

100 (104)

MUTANT

0 (0)

0 (0)

97.9 (91)

73.1 (57)

97.9 (92)

0 (0)

0 (0)

96.7 (87)

90.4 (94)

1.0 (1)

0 (0)

MIXED

0 (0)

0 (0)

0 (0)

19.2 (15)

0 (0)

0 (0)

1.1 (1)

1.1 (1)

5.8 (6)

1.0 (1)

0 (0)

MDH

WILD

100 (99)

100 (103)

10.7 (11)

24.3 (25)

5.8 (6)

100 (103)

98.9 (98)

13.2 (14)

11.9 (12)

100 (104)

100 (107)

MUTANT

0 (0)

0 (0)

87.4 (90)

70.9 (73)

94.2 (97)

0 (0)

1.0 (1)

86.8 (92)

86.1 (87)

0 (0)

0 (0)

MIXED

0 (0)

0 (0)

1.9 (2)

4.9 (5)

0 (0)

0 (0)

0 (0)

0 (0)

2.0 (2)

0 (0)

0 (0)

  1. Prevalence of Pfdhfr and Pfdhps wildtype, mutant and mixed genotypes per study site for the entire period was calculated as a percentage of the total number of samples successfully analysed over the study period per codon per the specific site.