Characteristic | Treatment arm | p-value | |
---|---|---|---|
AL (n = 416) | DP (n = 354) |  | |
Parasite persistence, n (%) | Â | Â | Â |
  Positive blood smear day 1 | 269 (67.6%) | 181 (52.2%) | <0.001 |
  Positive blood smear day 2 | 23 (5.6%) | 20 (5.7%) | 0.92 |
  Positive blood smear day 3 | 0 | 1 (0.3%) | N/A |
Fever persistence, n (%) | Â | Â | Â |
  Febrile* day 1 | 124 (30.0%) | 65 (18.4%) | 0.002 |
  Febrile* day 2 | 8 (1.9%) | 11 (3.1%) | 0.28 |
  Febrile* day 3 | 7 (1.7%) | 7 (2.0%) | 0.78 |
28-day WHO treatment outcome, n (%) | Â | Â | Â |
  Lost to follow-up | 16 (3.9%) | 13 (3.7%) |  |
  Early treatment failure | 0 | 1 (0.3%) |  |
  Late parasitological failure | 137 (32.9%) | 22 (6.2%) | < 0.001 |
  Late clinical failure | 74 (17.8%) | 7 (2.0%) |  |
  Adequate clinical and parasitological response | 189 (45.4%) | 311 (87.9%) |  |