Table 3 Associations between variables of interest and a positive blood slide on day 1

Anti-malarial treatment

DP

52.2%

1.0 (reference)

-

1.0 (reference)

-

AL

67.6%

1.30 (1.13-1.49)

<0.001

1.35 (1.21-1.50)

<0.001

mg/kg dosing of anti-malarial

≥ median (DP)

55.0%

1.0 (reference)

-

Not included in final model

< median (DP)

49.4%

0.96 (0.78-1.18)

0.68

≥ median (AL)

64.3%

1.0 (reference)

-

< median (AL)

70.7%

1.11 (0.96-1.28)

0.16

Temperature °C

< 37.0

48.2%

1.0 (reference)

-

1.0 (reference)

-

37.0-37.9

59.7%

1.22 (1.03-1.44)

0.02

1.09 (0.96-1.24)

0.19

≥ 38.0

71.2%

1.47 (1.25-1.73)

<0.001

1.17 (1.04-1.33)

0.01

Parasite density per μL

< 4,000

21.3%

1.0 (reference)

-

1.0 (reference)

-

4,000-20,000

57.4%

2.64 (1.93-3.63)

<0.001

2.62 (1.90-3.62)

<0.001

> 20,000

73.5%

3.39 (2.51-4.59)

<0.001

3.31 (2.44-4.49)

<0.001

Haemoglobin g/dL

≥ 10

60.0%

1.0 (reference)

-

Not included in final model

< 10

64.0%

1.08 (0.92-1.26)

0.33

HIV status

Negative

60.5%

1.0 (reference)

-

Not included in final model

Positive

58.3%

0.97 (0.72-1.31)

0.84

Episode number

1-2

59.9%

1.0 (reference)

Not included in final model

3-4

57.1%

0.94 (0.82-1.09)

0.42

≥ 5

65.0%

1.02 (0.90-1.17)

0.74