Skip to main content
Figure 4 | Malaria Journal

Figure 4

From: A novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway

Figure 4

Compound IC 50 curves determined for Plasmodium falciparum strain 3D7 and human HEK293 cells. A: IC50 curves of hits that confirmed in the CoA rescue at 2 μM compound concentration. IC50 curves against P. falciparum 3D7 are shown in black, against HEK293 in red; graphs depict n = 3 in duplicate or triplicate point each; error bars indicate +/- standard error of mean (SEM). B: IC50 curves of hits that did not confirm in the CoA rescue at 2 μM compound concentration. It was observed that these were generally the more potent antiplasmodial compounds. IC50 curves against P. falciparum 3D7 are shown in black, against HEK293 in red. Curves show n = 3 in duplicate or triplicate point each; error bars indicate +/- standard error of mean (SEM).

Back to article page