Gene locus | Number of isolates (%b) | |||
---|---|---|---|---|
Subtropical zone, | Temperate zone, | Total, | ||
n = 53 | n = 61 | n = 114 | ||
dhfr | Mutation at codon 13 | 0 (0) | 0 (0) | 0 (0) |
 | Mutation at codon 57 | 32 (60**) | 0 (0) | 32 (28) |
 | Mutation at codon 58 | 33 (62**) | 0 (0) | 33 (29) |
 | Mutation at codon 61 | 33 (62**) | 0 (0) | 33 (29) |
 | Mutation at codon 99 | 10 (19**) | 24 (40) | 34 (30) |
 | Mutation at codon 117 | 39 (74) | 35 (57) | 74 (65) |
 | Mutation at codon 173 | 0 (0) | 0 (0) | 0 (0) |
dhps | Mutation at codon 382 | 17 (32**) | 0 (0) | 17 (15) |
 | Mutation at codon 383 | 42 (79**) | 0 (0) | 42 (37) |
 | Mutation at codon 512 | 1 (2) | 0 (0) | 1 (1) |
 | Mutation at codon 553 | 15 (28**) | 0 (0) | 15 (13) |
 | Mutation at codon 585 | 0 (0) | 0 (0) | 0 (0) |
mdr-1 | Mutation at codon 976 | 5 (9**) | 0 (0) | 5 (4) |
 | Mutation at codon 1076 | 19 (36**) | 61 (100) | 80 (70) |