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Table 2 Prevalence of mutations conferring resistance to chloroquine and sulfadoxine-pyrimethemine in Plasmodium vivax isolates a

From: Molecular surveillance of pvdhfr, pvdhps, and pvmdr-1 mutations in Plasmodium vivax isolates from Yunnan and Anhui provinces of China

Gene locus

Number of isolates (%b)

Subtropical zone,

Temperate zone,

Total,

n = 53

n = 61

n = 114

dhfr

Mutation at codon 13

0 (0)

0 (0)

0 (0)

 

Mutation at codon 57

32 (60**)

0 (0)

32 (28)

 

Mutation at codon 58

33 (62**)

0 (0)

33 (29)

 

Mutation at codon 61

33 (62**)

0 (0)

33 (29)

 

Mutation at codon 99

10 (19**)

24 (40)

34 (30)

 

Mutation at codon 117

39 (74)

35 (57)

74 (65)

 

Mutation at codon 173

0 (0)

0 (0)

0 (0)

dhps

Mutation at codon 382

17 (32**)

0 (0)

17 (15)

 

Mutation at codon 383

42 (79**)

0 (0)

42 (37)

 

Mutation at codon 512

1 (2)

0 (0)

1 (1)

 

Mutation at codon 553

15 (28**)

0 (0)

15 (13)

 

Mutation at codon 585

0 (0)

0 (0)

0 (0)

mdr-1

Mutation at codon 976

5 (9**)

0 (0)

5 (4)

 

Mutation at codon 1076

19 (36**)

61 (100)

80 (70)

  1. aIsolates from subtropical (Yunnan province) and temperate (Anhui province) zones of China.
  2. bStatistically significant differences for comparison with isolates from temperate zone (Anhui province) of China (**P < 0.01) using u-test.