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Table 2 Parameter estimates for final population PK model: azithromycin in serum and chloroquine in plasma

From: Population pharmacokinetics of azithromycin and chloroquine in healthy adults and paediatric malaria subjects following oral administration of fixed-dose azithromycin and chloroquine combination tablets

Parameter (units)

PK parameter mean (%RSE)

Inter-individual variability %CV (%RSE)

PK parameter mean (%RSE)

Inter-individual variability %CV (%RSE)

 

Azithromycin

Chloroquine

CL/F (L/h)

100 (6.1)

31.3 (17.6)

59.1 (2.3)

30.5 (12.2)

Normalized for weight

0.75 FIXED

 

0.75 FIXED

 

V1/F (L)

186 (22.4)

113 (31.8)

2,870 (4.3)

46.6 (15.7)

Normalized for weight

1 FIXED

CL:V1 covariance 0.28

1 FIXED

CL:V1 covariance 0.72

Ka (1/h)

0.259 (10.2)

NE

6.12 (29.4)

NE

Q2/F (L/h)

180 (8.2)

NE

61.4 (11.3)

NE

Normalized for weight

0.75 FIXED

 

0.75 FIXED

 

V2/F (L)

2,890 (4.8)

NE

1,890 (4.9)

NE

Normalized for weight

1 FIXED

 

1 FIXED

 

LAG (h)

NE

NE

0.387 (6.7)

NE

Q3/F (L/h)

10.6 (19.0)

NE

NE

NE

V3/F (L)

2,610 (46.7)

NE

NE

NE

Residual error (%RSE)

0.406 (2.4)

NE

0.249 (2.6)

NE

  1. %CV, Percent coefficient of variation; %RSE, Relative standard error expressed as percentage; CL/F, Clearance normalized for bioavailability; IIV, Inter-individual variability; Ka, Absorption rate constant; LAG, Lag time; NE, Not estimated; PK, Pharmacokinetics; Q2/F, Inter-compartmental clearance from central to first peripheral compartment; Q3/F, Inter-compartmental clearance from central to second peripheral compartment; V1/F, Volume of distribution of the central compartment; V2/F, Volume of distribution of first peripheral compartment; V3/F, Volume of distribution of second peripheral compartment.