Parameter (units) | PK parameter mean (%RSE) | Inter-individual variability %CV (%RSE) | PK parameter mean (%RSE) | Inter-individual variability %CV (%RSE) |
---|---|---|---|---|
Azithromycin | Chloroquine | |||
CL/F (L/h) | 100 (6.1) | 31.3 (17.6) | 59.1 (2.3) | 30.5 (12.2) |
Normalized for weight | 0.75 FIXED | 0.75 FIXED | ||
V1/F (L) | 186 (22.4) | 113 (31.8) | 2,870 (4.3) | 46.6 (15.7) |
Normalized for weight | 1 FIXED | CL:V1 covariance 0.28 | 1 FIXED | CL:V1 covariance 0.72 |
Ka (1/h) | 0.259 (10.2) | NE | 6.12 (29.4) | NE |
Q2/F (L/h) | 180 (8.2) | NE | 61.4 (11.3) | NE |
Normalized for weight | 0.75 FIXED | 0.75 FIXED | ||
V2/F (L) | 2,890 (4.8) | NE | 1,890 (4.9) | NE |
Normalized for weight | 1 FIXED | 1 FIXED | ||
LAG (h) | NE | NE | 0.387 (6.7) | NE |
Q3/F (L/h) | 10.6 (19.0) | NE | NE | NE |
V3/F (L) | 2,610 (46.7) | NE | NE | NE |
Residual error (%RSE) | 0.406 (2.4) | NE | 0.249 (2.6) | NE |