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Table 1 Cumulative statistics of TK900D calibration standards and quality control samples

From: The development and validation of an LC-MS/MS method for the determination of a new anti-malarial compound (TK900D) in human whole blood and its application to pharmacokinetic studies in mice

Parameters

Calibration standards and nominal concentrations (ng/ml)

 

STD B

STD C

STD D

STD E

STD F

STD G

STD H

STD I

STD J

 

3.910

7.821

15.64

31.28

62.57

125.0

250.0

500.2

1000

Mean

4.051

7.524

15.48

30.94

64.10

126.6

251.7

496.6

996.3

% Nom

103.6

96.2

99.0

98.9

102.5

101.3

100.7

99.3

99.6

% CV

3.4

4.3

1.7

3.9

2.2

1.9

0.6

0.9

0.9

% Bias

3.6

-3.8

-1.0

-1.1

2.5

1.3

0.7

-0.7

-0.4

N

6

6

6

6

6

6

6

6

6

Parameters

Quality control samples and nominal concentration (ng/ml)

 

QC A

QC B

QC C

QC D

QC E

QC F

QC G

QC H DIL

 

3.909

10.01

20.01

60.03

160.1

400.2

800.0

1600

 

LLOQ

Low

----

----

Medium

----

High

Dilution

Mean

3.815

10.12

21.13

63.42

177.5

436.2

840.9

1673

% Nom

97.6

101.1

105.6

105.7

110.9

109.0

105.1

104.6

% CV

10.8

5.3

4.5

5.4

5.7

7.1

8.3

5.1

% Bias

-2.4

1.1

5.6

5.7

10.9

9.0

5.1

4.6

N

18

18

18

18

18

18

18

6

  1. QCH DIL was used to establish the dilution linearity of the method.