Parameters | TK900D | TK900E | ||||||
---|---|---|---|---|---|---|---|---|
Orala | IVa | Orala | IVa | |||||
Nominal dose (mg/kg) | 40 | 20 | 5.0 | 2.5 | 40 | 20 | 5.0 | 2.5 |
Apparent t 1/2 (h) | 3.9 | 6.0 | 2.3 | 1.9 | 4.0 | 3.6 | 2.5 | 1.6 |
Blood CL total (ml/min/kg) | —b | —b | 44.8 | 48.9 | —b | —b | 51.0 | 51.2 |
Vd (l/kg) | —b | —b | 8.9 | 7.9 | —b | —b | 10.3 | 7.0 |
Vss (l/kg) | —b | —b | 9.1 | 8.7 | —b | —b | 12.6 | 6.5 |
C max (μM) | 0.79 | 0.54 | —b | —b | 2.81 | 0.94 | —b | —b |
T max (h) | 1.4 | 1.4 | —b | —b | 1.0 | 0.8 | —b | —b |
AUC 0 - ∞ (min. μmol/l) | 287 | 256 | 222 | 104 | 541 | 222 | 221 | 107 |
Bioavailability (%) | 16.2 | 30.8 | —b | —b | 30.6 | 25.9 | —b | —b |