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Table 5 Pharmacokinetic parameters for TK900D and TK900E in male C57/BL6 mice

From: The development and validation of an LC-MS/MS method for the determination of a new anti-malarial compound (TK900D) in human whole blood and its application to pharmacokinetic studies in mice

Parameters

TK900D

TK900E

Orala

IVa

Orala

IVa

Nominal dose (mg/kg)

40

20

5.0

2.5

40

20

5.0

2.5

Apparent t 1/2 (h)

3.9

6.0

2.3

1.9

4.0

3.6

2.5

1.6

Blood CL total (ml/min/kg)

b

b

44.8

48.9

b

b

51.0

51.2

Vd (l/kg)

b

b

8.9

7.9

b

b

10.3

7.0

Vss (l/kg)

b

b

9.1

8.7

b

b

12.6

6.5

C max (μM)

0.79

0.54

b

b

2.81

0.94

b

b

T max (h)

1.4

1.4

b

b

1.0

0.8

b

b

AUC 0 - ∞ (min. μmol/l)

287

256

222

104

541

222

221

107

Bioavailability (%)

16.2

30.8

b

b

30.6

25.9

b

b

  1. aValues are the mean of 5 animals, bEmpty cells indicate that the value was measured or was not relevant.