Heterogeneous genetic diversity pattern in Plasmodium vivax genes encoding merozoite surface proteins (MSP) -7E, −7F and -7L

Table 4 Average number of msp-7 gene synonymous divergence per synonymous site (K _S ) and non-synonymous divergence per non-synonymous site (K _N )

n	Gene	5′ end		Central		3′ end		Full-length gene
Worldwide isolates		K_S(SE)	K_N(SE)	K_S(SE)	K_N(SE)	K_S(SE)	K_N(SE)	K_S(SE)	K_N(SE)
36	*msp-7E*	0.0746 (0.0156)•	0.0126 (0.0034)	0.0813 (0.0185)	0.1976 (0.0191)•	0.0980 (0.0163)•	0.0299 (0.0056)	0.0833 (0.0092)	0.0676 (0.0066)
42	*msp-7F*	0.0098 (0.0023)†	0.0047 (0.0009)	0.0146 (0.0029)	0.0141 (0.0022)	0.0086 (0.0022)	0.0100 (0.0022)	0.0110 (0.0014)	0.0096 (0.0010)
37	*msp-7L*	0.0140 (0.0031)‡	0.0092 (0.0017)	0.0172 (0.0035)	0.0149 (0.0020)	0.0111 (0.0025)‡	0.0070 (0.0013)	0.0139 (0.0017)*	0.0102 (0.0010)
Colombian isolates
32	*msp-7E*	0.0755 (0.0151)•	0.0128 (0.0032)	0.0808 (0.0183)	0.1963 (0.0191)•	0.0982 (0.0156)•	0.0305 (0.0053)	0.0834 (0.0089)	0.0676 (0.0065)
37	*msp-7F*	0.0111 (0.0027)†	0.0053 (0.0011)	0.0165 (0.0033)	0.0156 (0.0023)	0.0098 (0.0025)	0.0110 (0.0022)	0.0125 (0.0016)	0.0107 (0.0011)
32	*msp-7L*	0.0156 (0.0037)‡	0.0107 (0.0020)	0.0199 (0.0041)	0.0170 (0.0023)	0.0123 (0.0027)‡	0.0081 (0.0015)	0.0157 (0.0019)*	0.0118 (0.0011)

SE: standard error. 5′-end (pvmsp-7E: nucleotide 1–390, pvmsp-7F: nucleotide 1–432, pvmsp-7L: nucleotide 1–381), central (pvmsp-7E: nucleotide 391–747, pvmsp-7F: nucleotide 433–1,053, pvmsp-7L: nucleotide 382–816) and 3′-end (pvmsp-7E: nucleotide 748–1,158, pvmsp-7F: nucleotide 1,054–1,449, pvmsp-7L: nucleotide 817–1,275). Numbering based on Additional files4,9 and10. ‡: p <0.09, *: p <0.04, †: p <0.02, •: p <0.001.

ISSN: 1475-2875