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Table 2 Per protocol analysis of clinical outcome of artesunate-amodiaquine treatment in southern Mauritania

From: Efficacy of artesunate-amodiaquine for the treatment of acute uncomplicated falciparum malaria in southern Mauritania

Outcome

Kobeni

Timbedra

Number of enrolled patients

65

65

Exclusion after enrollment (before PCR correction), n

7

2

Lost-to-follow-up, n

0

8

Per protocol population (before PCR correction), n

58

55

PCR-uncorrected outcome

  

 Early treatment failure, n (%)

0

0

 Late clinical failure (LCF), n (%)

2 (3.4)

1 (1.8)

 Late parasitological failure, n (%)

0

0

 Adequate clinical and parasitological response, n (%)

56 (96.6)

54 (98.2)

Per protocol population after PCR correction, n*

57

55

PCR-corrected outcome

  

 Early treatment failure, n (%)

0

0

 Late clinical failure (LCF) due to recrudescence, n (%)

1 (1.8)

1 (1.8)

 Late parasitological failure, n (%)

0

0

 Adequate clinical and parasitological response, n (%)

56 (98.2)

54 (98.2)

Patients with fever on day 1, n (%)

13 (22.4)

7 (12.7)

Patients with fever on day 2, n (%)

2 (3.4)

0

Patients with fever on day 3, n (%)

0

0

Patients with parasitaemia on day 2, n (%)

46 (79.3)

25 (45.5)

Patients with parasitaemia on day 3, n (%)

0

0

  1. *In Kobeni, one patient was excluded (i.e., censored) after PCR correction due to re-infection.