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Table 1 Patient characteristics

From: Fixed dose artesunate amodiaquine – a phase IIb, randomized comparative trial with non-fixed artesunate amodiaquine

Characteristic FD ASAQ NF ASAQ P value
N = 26 N = 28
Age 23.1 (17.9-60.1) 24.2 (18.1-56.9) 0.98
Gender (n, M/F) 12/14 13/15 0.98
Luo ethnic group [N(%)] 23 (88.5) 24 (85.7) 1.00
Symptoms [N(%)]
 Headache 23 (88.5) 26 (92.9) 0.66
 Anorexia 18 (69.2) 14 (50.0) 0.15
 Nausea 16 (61.5) 17 (60.7) 0.95
 Weakness 13 (50.0) 15 (53.6) 0.79
 Vomiting 12 (46.2) 16 (57.1) 0.42
 Abdominal pain 10 (38.5) 13 (46.4) 0.55
 Diarrhoea 3 (11.5) 6 (21.4) 0.47
 Cough 1 (3.8) 4 (14.3) 0.35
Signs (range)
 Weight (kg) 58.0 (50.0-90.0) 60.0 (39.0-82.0) 0.78
 Temperature (°C) 37.2 (36.0-39.0) 37.2 (35.8-40.0) 0.42
 Pulse rate (beats/min) 92.5 (62.0-124.0) 90.5 (57.0-131.0) 0.90
 Systolic blood pressure (mmHg) 119.5 (90.0-157.0) 125.5 (85.0-160.0) 0.48
 Diastolic blood pressure (mmHg) 70.0 (55.0-92.0) 74.0 (51.0-99.0) 0.37
 Palpable spleen 0 1/27 (3.7) 1.0
 Palpable liver 0 0 -
Laboratory results (range)
 Asexual parasitaemia/µL 18,479 (8,927-33,915) 13,742 (5,069-23,948) 0.56
 Gametocyte carriage (n, %) 1 (3.8) 0 (0.0) 0.48
 Haemoglobin (g/dL) 13.3 (10.3-17.6) 13.2 (9.9-17.7) 0.53
 White blood cells (× 103/µL) 5.6 (5.2-6.8) 5.1 (2.3-9.5) 0.09
 Neutrophils (× 103/µL) 3.5 (1.3-5.6) 2.6 (0.8-8.1) 0.02
 Lymphocytes (× 103/µL) 1.3 (0.5-2.5) 1.3 (0.5-3.3) 0.22
 Monocytes (× 103/µL) 0.8 (0.6-1.1) 0.6 (0.4-0.8) 0.005
 Eosinophils (× 103/µL) 0.07 (0.03-0.58) 0.08 (0.05-0.19) 0.60
 Platelets (× 103/µL) 96.0 (44.0-229.0) 95.5 (18.0-254.0) 0.86
 AST* (IU/L) 28.0 (13.4-82.9) 31.2 (15.1-56.1) 0.99
 ALT* (IU/L) 21.6 (10.5-123.1) 23.2 (3.8-105.9) 0.37
 Total bilirubin (µmol/L) 12.0 (1.7-50.6) 13.1 (0.0-65.3) 0.74
 Creatinine (µmol/L) 70.7 (17.7-113.2) 75.6 (53.0-114.9) 0.26
  1. All continuous data are expressed as median (range).
  2. *AST – aspartate aminotransferase, ALT- alanine aminotransferase.
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