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Table 4 Summary of mean (standard deviation) and mean changes in haematological and biochemical data

From: Fixed dose artesunate amodiaquine – a phase IIb, randomized comparative trial with non-fixed artesunate amodiaquine

  D0 D7 D28 p p
D7-D0 D7-D0 D28-D0 D28-D0
Haematology
 Haemoglobin (g/dL) 13.4 (2.1) 12.0 (1.8) 12.6 (1.8) −1.4 <0.000 −0.8 <0.000
 White blood cells* 5.4 (1.4) 6.3 (1.9) 5.6 (2.3) 0.9 0.0012 0.3 0.44
 Neutrophils* 3.1 (1.4) 2.6 (1.1) 2.2 (1.5) −0.4 0.046 −0.9 0.00046
 Lymphocytes* 1.3 (0.6) 2.6 (0.9) 2.4 (0.9) 1.2 <0.000 1.0 <0.0000
 Monocytes* 0.71 (0.28) 0.66 (0.26) 0.48 (0.24) −0.05 0.25 −0.22 <0.000
 Eosinophils* 0.13 (0.16) 0.37 (0.43) 0.41 (0.47) 0.24 <0.000 0.28 <0.0000
 Platelets* 96.0 (18–254) 234 (187–311) 175 (140–213) 126.0 <0.000 81.0 <0.0000
Biochemistry
 AST (U/L) 32.9 (13.2) 33.0 (18.7) 28.3 (11.0) 1.1 0.68 −4.4 0.0268
 ALT (U/L) 29.5 (21.8) 33.8 (20.8) 22.0 (10.2) 5.7 0.03 −8.1 0.005
 Total bilirubin 16.9 (14.8) 7.2 (7.9) 7.0 (6.6) −10.0 <0.000 −9.4 0.00014
 Creatinine 73.5 (20.3) 71.8 (17.6) 71.9 (27.4) −2.3 0.50 −3.4 0.48
  1. *x 103/µL; µmol/L; median (range); AST – aspartate aminotransferase; ALT- alanine aminotransferase.
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