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Table 5 Median (interquartile range) and median changes from baseline of the Bazett’s corrected QT interval, heart rate, and PR and QRS intervals for both artesunate amodiaquine arms combined*

From: Fixed dose artesunate amodiaquine – a phase IIb, randomized comparative trial with non-fixed artesunate amodiaquine

Statistical parameter Median Lower quartile Upper quartile vs D0 p vs D0 Median Lower quartile Upper quartile vs D0 p vs D0
Variable QTcB interval ms Heart rate b/min
D0, pre-dose 410 394 425    92 80 103   
D0 + 2 h 412 398 428 2 0.3652 85 74 98 −5 0.0012
D0 + 4 h 416.5 397 429 3.5 0.2593 79 71 89 −8.5 <.0001
D2, pre-dose 411 388 423 −4.5 0.2551 59 53 64 −35 <.0001
D2 + 2 h 415 393 433.5 3 0.4897 59.5 54 64.5 −36 <.0001
D2 + 4 h 420 400 431 7.5 0.0059 59 55 65 −31.5 <.0001
D28 398 384 418 −10.5 0.0016 66 59 74 −25 <.0001
Variable QRS interval ms PR interval ms
D0, pre-dose 78 72 88    151.5 140.5 172.5   
D0 + 2 h 82 72 89 2 0.2572 158 146 176 5 0.0061
D0 + 4 h 82 76 88 1.5 0.1122 161 153 175 10 <.0001
D2, pre-dose 84 74 96 2.5 0.0084 163 154 185 12 <.0001
D2 + 2 h 85 79 95.5 6 0.0001 167 155.5 184.5 13.5 <.0001
D2 + 4 h 86 78 95 5 0.0003 172 151 187 15 <.0001
D28 86 76 92 5.5 0.0073 164 147 179 12 <.0001
  1. *Only the QTcB data are normally distributed but the median interquartile ranges are shown for all parameters for clarity.
  2. Corresponding mean 95% confidence intervals are: 9.02 (2.72-15.31) ms.
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