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Table 6 Final random effects model summarizing the significant, independent factors to explain the changes in the QTcB interval over time

From: Fixed dose artesunate amodiaquine – a phase IIb, randomized comparative trial with non-fixed artesunate amodiaquine

Effect

Sex

Estimate

Standard error

DF

t Value

Pr > |t|

Intercept

 

373.06

9.3613

52

39.85

<0.0001

Time

 

−0.016

0.00421

296

−3.8

0.0002

Age

 

0.4153

0.215

296

1.93

0.0543

Sex

F

20.8761

4.6453

296

4.49

<0.0001

Sex

M

0

.

.

.

.

ECG heart rate

 

0.1461

0.06916

296

2.11

0.0355

DAQ concentrations

 

0.02972

0.01026

296

2.9

0.0041