Table 1 Base-case values and ranges used in sensitivity analysis

Costs (2012 USD)

Disease costs

Medical costs

Mild malaria

Public health systems

0.51

0.26

0.77

[27] (±50%)

Households

0.50

0.21

1.00

[28] (±50%)

Severe malaria (CM, SMA)

Public health systems

12.76

6.38

19.14

[27] (±50%)

Households

0.50

0.21

1.00

[28] (±50%)

Non-medical costs

(Productivity costs)

Mild, CM, SMA

Adults

2.52

1.26

3.78

[16, 27] (±50%)

Children

1.11

0.56

1.67

[16, 27] (±50%)

Death

4.76

2.38

7.14

[16] (±50%)

Vaccine costs

Price per dose

7

1

15

[29, 30] (Min, Max)

Administration per dose

0.37

0.19

0.57

[30] (±50%)

Total costs for 3 doses

22.11

3.57

46.71

LLINs costs

LLIN per two persons

3.16

2.23

5.23

[31, 32] (Min, Max)

DALY-related parameters

Life expectancy

47.1 years

[23]

Disability weights

[33]

Mild malaria

0.191

0.172

0.211

CM

0.471

0.443

0.471

SMA

0.471

0.191

0.471

Death

1

Effectiveness parameters

Vaccine protection efficacy

Mild Malaria

0.539

0.496

0.578

[12] (95% CI)

Severe Malaria (CM, SMA)

0.313

0.142

0.448

[12] (95% CI)

Death

0.2

0.15

0.25

[19] (±25%)

Duration of protection

45 months

11 months

10 years

[14]

Vaccine coverage

0.85

0.64

0.99

[34, 35] (Min, Max)

LLIN protection efficacy

Mild Malaria

0.5

0.43

0.62

[36] (Min, Max)

Severe Malaria (CM, SMA)

0.45

0.2

0.63

[36] (95% CI)

Death

0.17

0.1

0.24

[36] (95% CI)

Duration of protection

3 years

3 years

5 years

[37] (Min, Max)

LLIN coverage

80%

55.4%

80%

[7] (Baseline (2010) - Target (2015))

LLIN use

88%

87%

90%

[38] (95% CI)

Discount rate%

3%

0%

6%

[39]