Table 1 Summary of published cases of severe and complicated P. ovale infection

This case report

42 yr

Male

None

Kalia, Guinea: 6 months ago Mozambique: 1 month ago

None

1-6 months

1.4%

Jaundice, respiratory distress, hypotension, incipient bleeding

IV quinine, 14 days primaquine

Recovered

Lee et al. [16]

31 yr

Female

None

Ghana

Mefloquine

10 months

0.1%

ARDS

Chloroquine, 14 days primaquine

Recovered

Rojo Marcos et al. [17]

43 yr

Male

Hypertensive, diabetic

Nigeria

None

N/S

6,000/μL

ARDS

Chloroquine, 14 days primaquine

Recovered

Haydoura et al. [18]

46 yr

Female

Methylenetetrahydrofolate reductase mutation with secondary portal vein thrombosis

Acquired by transfusion

N/A

1 month following transfusion

1.11%

ARDS

IV quinine and doxycycline, 14 days primaquine

Recovered

Roze et al. [19]

24 yr

Male

Tuberous sclerosis

Chad, Ivory Coast

Doxycycline

1 year

0.1%

ARDS

Chloroquine then changed to quinine

Recovered

Lau et al. [20]

59 yr

Male

None

Victoria Island, Nigeria

Mefloquine

6 months

0.18%

ARDS, acute renal failure, metabolic acidosis

Chloroquine plus primaquine, changed to quinine, then artesunate

Demised

Hashimi et al. [21]

31 yr

Male

Previous pulmonary tuberculosis (20 years ago)

Democratic Republic of Congo

N/S

7 months

0.2%

ARDS

IV quinine

Demised

Facer et al. [23]

51 yr

Female

N/S

Ghana

None

12 days

1.8%

Splenic rupture

None

Demised

Patel et al. [24]

42 yr

Male

N/S

South and Central Africa

Hydroxychloroquine, discontinued during travel

18 months

N/S

Splenic rupture

Chloroquine and primaquine

Recovered

Cinquetti et al. [25]

34 yr

Male

None

Senegal 2002, Ivory Coast 2004

Doxycycline

2-4 years

0.001%

Splenic infarction

IV quinine

Recovered