Transmission dynamics of vivax malaria in Korea: effectiveness of anti-malarial chemoprophylaxis
© Endo and Nishiura; licensee BioMed Central Ltd. 2014
Published: 22 September 2014
Vivax malaria with two distinct (short- and long-term) incubation periods has been prevalent in the Republic of Korea since its re-emergence in 1993. Chemoprophylaxis has been conducted among military personnel since 1997. We estimated the time-dependent reproduction number, thereby assessing the protective effect of chemoprophylaxis.
Materials and methods
A mathematical model has been formulated using a renewal equation, estimating the yearly reproduction number (Ry) from 1993 to 2012 by maximum likelihood estimation method. We also computed Akaike Information Criterion (AIC) to test if there was a detectable change point in the trend in relation to chemoprophylaxis.
Three-year average of Ry showed gradual decline through 1993-2012 with a temporary increase from 2003 to 2005, having been under the threshold 1 since 1998. AIC has suggested that the chemoprophylaxis has cut down Ry by 34% from what it would be without chemoprophylaxis.
The epidemic of vivax malaria in Korea has been brought under control due mainly to mass-chemoprophylaxis.
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