Table 2 PK parameters of NP046
From: Efficacy and pharmacokinetic evaluation of a novel anti-malarial compound (NP046) in a mouse model
PK parameter | Oral | IV | |
|---|---|---|---|
Nominal Dose (mg/kg) | 50 | 10 | 5 |
Apparent t 1/2 (h) | 4.4 ± 0.60 | 3.1 ± 0.46 | 3.2 ± 0.35 |
Blood CL total (mL/min/kg) | — | — | 62.2 ± 3.0 |
Vd (L/Kg) | — | — | 16.9 ± 1.3 |
C max (μM) | 0.47 ± 0.10 | 0.13 ± 0.06 | — |
T max (min) | 30 | 48 | — |
AUC 0 - ∞ (min. μmol/L) | 80 ± 8.8 | 30 ± 14.7 | 248 ± 12.6 |
Bioavailability (%) | 3.2 ± 0.47 | 6.0 ± 2.9 | N/A |