Compounds | IC50 (μM) | IC90 (μM) | Index of selectivity |
---|
AD2646 (-)
| 4.9 | 7.5 | 160 |
AD2645 (+)
| 6.1 | 10.3 | 161 |
AD2672 (-)
| 3.7 | 5.9 | 2 |
AD2730 (-)
| 6.1 | 9.9 | 322 |
AD2729 (-)
| 5.8 | 9.8 | 22 |
AD2619 (-)
| 26.7 | 42.3 | 624 |
PPMP
| 7.5 | 12.4 | 0.8 |
- IC50 and IC90 values are the mean of three independent experiments. The S.E. were within 10% of the mean. (-): D-threo, (+): L-threo. Index of selectivity is defined by the ratio of the IC50 value on MRC-5 cells to that on P. falciparum.