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Table 1 Cytotoxicity of methylene analogs and PPMP on human MRC-5 cells

From: Anti-Plasmodium activity of ceramide analogs

Compounds

IC50 (μM)

IC90 (μM)

Index of selectivity

AD2646 (-)

4.9

7.5

160

AD2645 (+)

6.1

10.3

161

AD2672 (-)

3.7

5.9

2

AD2730 (-)

6.1

9.9

322

AD2729 (-)

5.8

9.8

22

AD2619 (-)

26.7

42.3

624

PPMP

7.5

12.4

0.8

  1. IC50 and IC90 values are the mean of three independent experiments. The S.E. were within 10% of the mean. (-): D-threo, (+): L-threo. Index of selectivity is defined by the ratio of the IC50 value on MRC-5 cells to that on P. falciparum.