Table 1 Comparison of studies during which a rebound effect was observed upon termination of drug treatment. Studies are in the order they are cited in the text.
Drug used (country) | Ages of study group | Duration of treatment | Duration of post-intervention follow-up | Effect on malaria morbidity | Rebound effect | Reference |
|---|---|---|---|---|---|---|
P-D1 (Tanzania) | 2 mo. at start of study | Weekly for one year | One year after termination of treatment | Reduced incidence of clinical malaria by 40% during treatment period | 80% higher incidence of clinical episodes in treated group during the year following termination of treatment | [17] |
P-D (The Gambia) | 3 mo. at start of study | Every 2 weeks for maximum of 5 years | 5 years | 65% reduction in malaria episodes after 3 years of chemoprophylaxis | 52% more cases in treated group during the year following termination of treatment | [18, 22] |
SP2 + artesunate (The Gambia) | Entire villages, all ages | MDA3 1 dose | 20 weeks | Reduced rate of malaria attacks in children <11 yr by 60% | Rate of clinical malaria was 69% higher in treated groups 3 months after treatment | [25] |
SP (Mali) | 3 mo. to 20 years | MDA 1 dose | 24 weeks | Reduced incidence of first malaria episode from 26% to 3% during first month | Incidence of first malaria episodes in treated group rose to 42% compared to 17% (untreated group) during the third month after treatment | [26] |