Figure 4

P. yoelii 17XL infection upregulates RANTES protein expression in plasma and mouse brain. Comparative analysis of RANTES (7.8 kDa) protein expression in brain tissue samples (A) and plasma (B) from P. yoelii 17XL-infected mice days two, four, six, & eight post-infection (black bars) versus uninfected controls (grey bars). Brain tissue protein and plasma samples from infected and uninfected mice were analysed for RANTES expression by Western Blot and ELISA respectively. Densitometric data of Western blots were log-transformed (to adjust for small sample size) and represent the mean and ± SEM of infected (n = 5) and control (n = 5) cases, normalized to those for atubulin. Asterisk(s) indicate statistically significant differences between P. yoelii 17XL-infected and control groups.