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Table 1 Mobile phase compositions for the separation of preservatives by TLC (detected at 254 nm)

From: Post-marketing assessment of content and efficacy of preservatives in artemisinin-derived antimalarial dry suspensions for paediatric use

 

Retardation factor (RF)

Mobile phase (v/v/v)

Methylparaben

Propylparaben

Sorbic acid

Benzoic acid

CH3OH/H2O (80/20)

0.70

0.57

0.68

0.69 (Faint spot)

CH3OH/H2O/CH3COOH (70/30/1)

0.47

0.28

0.47

0.50 (Faint spot)

CH3OH/H2O/CH3COOH (80/20/1)

0.75

0.67

0.75

0.75

CH3OH/H2O/CH3COOH (80/20/3)

0.57

0.48

0.64

0.64 (Faint spot)

CH3OH/H2O/NH3 (80/20/1)

0.80

0.70

0.87

Highly faint spot

CH3CN/H2O/CH3COOH (95/5/1)

0.88

0.81

0.84

Highly faint spot

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Malaria Journal

ISSN: 1475-2875

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