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Table 2 Secondary parameters to be included in WARN Pharmacokinetic Database, if available.

From: World Antimalarial Resistance Network (WARN) IV: Clinical pharmacology

Patient characteristics

Antimalarial

Methodology

Pharmacokinetic parameters

Height

Directly Observed Therapy (DOT) [1]

Method for separating free drug

Primary parameters: Absorption rate constant (Ka); Elimination Rate constant (Ke), Volume of distribution; Clearance rate.

Vomiting

Batch number & Expiry Date

Sample handling

Secondary parameters: Cmax, tmax, elimination half-life;

Diarrhoea

Method of Administration [2]

 

Total vs free drug

Baseline parasite density

Co-administration [3]

 

Metabolites

Haematocrit, Bilirubin, Creatinine, Albumin (alpha1 glycoprotein, lipoprotein)

   

Ethnicity

   
  1. Footnotes to Table 2
  2. DOT: All doses supervised; First dose supervised; Unsupervised.
  3. 2. Administration: Whole tablets; Divided tablets; Crushed tablets.
  4. 3. Co-administration: Water; Fat content; Sugar water; Concomitant medication