From: World Antimalarial Resistance Network (WARN) IV: Clinical pharmacology
Patient characteristics | Antimalarial | Methodology | Pharmacokinetic parameters |
---|---|---|---|
Height | Directly Observed Therapy (DOT) [1] | Method for separating free drug | Primary parameters: Absorption rate constant (Ka); Elimination Rate constant (Ke), Volume of distribution; Clearance rate. |
Vomiting | Batch number & Expiry Date | Sample handling | Secondary parameters: Cmax, tmax, elimination half-life; |
Diarrhoea | Method of Administration [2] | Â | Total vs free drug |
Baseline parasite density | Co-administration [3] | Â | Metabolites |
Haematocrit, Bilirubin, Creatinine, Albumin (alpha1 glycoprotein, lipoprotein) | Â | Â | Â |
Ethnicity | Â | Â | Â |