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Figure 1 | Malaria Journal

Figure 1

From: Induction of multi-antigen multi-stage immune responses against Plasmodium falciparum in rhesus monkeys, in the absence of antigen interference, with heterologous DNA prime/poxvirus boost immunization

Figure 1

Antigen-specific antibody responses against pre-erythrocytic antigens Pf CSP, Pf SSP2/TRAP, Pf LSA1 and blood stage antigens Pf AMA1 and Pf MSP1. Sera from monkeys immunized with either CSP/PBS or CSLAM/PBS were assayed against Pf CSP, Pf SSP2/TRAP, Pf LSA1, Pf AMA1 or Pf MSP1 capture antigens by ELISA. Data are presented as the geometric means of titers at OD 0.5 units from individual monkeys per group. ELISA responses were classified as positive if (1) OD0.5 unit titer was > 10; and (2) the seroconversion index (ratio of titer post-immunization to titer pre-immunization) was > 4. Preimmun = preimmunization; 4wksDNA_1 = 4 wks post 1st DNA immunization; 4wksDNA_2 = 4 wks post 2nd DNA immunization; 4wksDNA_3 = 4 wks post 3rd DNA immunization; 4wksVirus = 4 wks post ALVAC-Pf 7 boost; 12 wksVirus = 12 wks post ALVAC-Pf 7 boost.

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