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Figure 4 | Malaria Journal

Figure 4

From: Induction of multi-antigen multi-stage immune responses against Plasmodium falciparum in rhesus monkeys, in the absence of antigen interference, with heterologous DNA prime/poxvirus boost immunization

Figure 4

A. Frequency of IFN-γ ELIspot responders to all CSLAM antigen components in CSLAM/PBS immunized monkeys. Monkeys were immunized with CSLAM/PBS, and PBMC collected at time points as defined in the legend to Figure 2 were assayed against recombinant Pf CSP, Pf LSA1, Pf AMA1 or Pf MSP1 protein and PfSSP2/TRAP peptide pools by IFN-γ ELIspot. B. Magnitude of IFN-γ ELIspot responses to all CSLAM antigen components in CSLAM/PBS immunized monkeys. Monkeys were immunized with CSLAM/PBS and PBMC collected at defined time points were assayed against recombinant P fCSP, Pf LSA1, Pf AMA1 or Pf MSP1 protein and Pf SSP2/TRAP peptide pools by IFN-γ ELIspot. Time point number 1, 2, 3, 4, 5, and 6 represent time points pre-immunization, 4 wks post 1st DNA immunization, 4 wks post 2nd DNA immunization, 4 wks post 3rd DNA immunization, 4 wks post ALVAC-Pf 7 boost, and 12 wks post ALVAC-Pf 7 boost, for monkeys PH1019, ROk6, RQk6, ROa7 and RBsG, respectively.

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Malaria Journal

ISSN: 1475-2875

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