Table 3 Parameter estimates obtained from fitting the 3-parameter sigmoid curve to the data presented in the example using a Bayesian approach (Gibbs sampling) (fitted using WinBUGS^®)

EC ₅₀

γ

Emax

Artesunate (A)

21.3 (17.5 – 30.5)

59.7 (14.0 – 98.1)

0.95 (0.91 – 0.99)

Halofantrine (B)

43.7 (34.8 – 61.0)

61.3 (15.3 – 98.0)

1.09(1.00 – 1.19)

Mefloquine (C)

154 (123 – 215)

61.8 (16.2 – 98.2)

1.5(1.10 – 1.20)

Mefloquine (D)

150 (119 – 217)

57.0 (9.85 – 97.9)

1.25 (1.09 – 1.40)

Chloroquine (E)

873 (710 – 1294)

42.6 (6.2 – 78.2)

0.78 (0.71 – 0.85)

Chloroquine (F)

540 (461 – 673)

3.75 (2.52 – 55.2)

0.92 (0.88 – 0.97)