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Table 3 Prevalence of pfcrt and pfmdr1 alleles in post-treatment samples of Nigerian children with acute uncomplicated malaria.

From: Rapid detection of Pfcrt and Pfmdr1 mutations in Plasmodium falciparum isolates by FRET and in vivo response to chloroquine among children from Osogbo, Nigeria

Allele

Frequency

Treatment outcome (%)

 
  

Cured N = 72

Failed N = 44

P. value

N = 116

    

Pfcrt T 76

86 (74%)

51 (71%)

41 (93%)

 

Pfcrt K 76

11 (12%)

11 (15%)

0 (0%)

0.003*

T76+K76

19 (14%)

10 (14%)

9 (20%)

 

N = 116

    

Pfmdr1 Y86

34 (29%)

22 (31%)

12 (27%)

 

Pfmdr1 N86

74 (64%)

47 (65%)

27 (61%)

n.s.

Y86+N86

8 (7%)

3 (4%)

5 (11%)

 

N = 116

    

Pfmdr1 F184

74 (64%)

45 (63%)

29(65%)

 

Pfmdr1 Y 184

35 (30%)

24 (33%)

11 (25%)

n.s.

F184+Y184

7 (6%)

3 (4%)

4 (9%)

 

N = 116

    

T76 + Y86

37 (32%)

21 (29%)

16 (36%)

 

K76 + N86

7 (6%)

7 (10%)

0 (0%)

0.028*

Mixed

72 (62%)

44 (61%)

28 (64%)

 

N = 116

    

T76 + F186

73 (63%)

40 (56%)

33 (75%)

 

K76 + Y184

2 (2%)

2 (3%)

0 (0%)

n.s.

Mixed

41 (35%)

30 (42%)

11 (25%)

 

N = 116

    

T76+Y86+F184

35 (30%)

19 (26%)

16 (36%)

 

K76+N86+Y184

3 (3%)

3 (4%)

0 (0%)

n.s.

Mixed

78 (67%)

50 (70%)

28 (64%)

 
  1. n.s. is not significant