Table 1 Physiological and clinical variables during first 7 days of RICU stay demonstrating the effect of the infusion of Drotrecogin alfa (activated) on days 1–4.
Variables | Day 0 | Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 |
|---|---|---|---|---|---|---|---|---|
Heart rate (/minute) | 128 | 111 | 120 | 116 | 106 | 100 | 92 | 86 |
Respiratory rate (/minute) | 46 | 32 | 36 | 30 | 28 | 28 | 24 | 22 |
Temperature (C) | 39 | 38.5 | 38.4 | 38 | 37 | 37 | 37 | 37.2 |
pH | 7.2 | 7.25 | 7.26 | 7.3 | 7.34 | 7.42 | 7.44 | - |
PaO2/FiO2 | 168 | 180 | 130 | 230 | 260 | 290 | 340 | - |
HCO3 (mEq/L) | 13 | 15 | 14 | 18 | 20 | 22 | 22 | - |
Ventilatory mode | Spontaneous | ACMV | ACMV | ACMV | PSV | T-piece | Spontaneous | Spontaneous |
PEEP (cm H20) | - | 8 | 10 | 6 | 5 | - | - | - |
Serum creatinine (mg/dL) | 5.2 | 6.0 | 5.2 | 7.1 | 4.6 | 4.4 | 4.0 | 3.6 |
Urine output (mL/24 hours) | 460 | 100 | 110 | 200 | 240 | 200 | 270 | 560 |
Serum bilirubin (mg/dL) | 18.2 | 18.9 | 18.2 | 15.4 | 9.1 | 8.4 | 6.0 | 4.2 |
Total leucocyte count (/μL) | 19000 | 19500 | 18200 | 14400 | 11400 | 8100 | 8000 | 8100 |
Platelet count (/μL) | 92000 | 105,000 | 155,000 | 183,000 | 212,000 | 241,000 | 260,000 | 270,000 |