Efficacy of antimalarial treatment in Guinea: in vivo study of two artemisinin combination therapies in Dabola and molecular markers of resistance to sulphadoxine-pyrimethamine in N'Zérékoré

Table 4 Frequency of individuals with molecular makers associated to SP resistance, Lainé refugee camp

Prevalence	No of individuals (Single+majority+mixed aplotypes)	%	95% CI
*dhps* (N = 135)
Double mutant 437&540	14 (6+2+6)	10.4	5.8–16.8
Double mutant 436&437	36 (22+7+7)	26.7	19.4–35.0
*dhfr* (N = 160)
triple mutant 51–59–108	137 (121+5+11)	85.6	79.2–90.7
*dhfr* and *dhps* (N = 135)
triple mutant 51–59–108 with double mutant 437&540	13 (6+2+5)	9.6	5.2–15.9

Single aplotype: only one single nucleotide polymorphism (SNP) was present
Majority aplotype: volume minority SNP value was more than half of the volume of the majority SNP
Mixed aplotype: volume minority SNP value was less than half of the volume of the majority SNP [9]

ISSN: 1475-2875