A major genetic locus controlling natural Plasmodium falciparum infection is shared by East and West African Anopheles gambiae

Table 1 Mapping of the EA_Pfin1 locus.

Marker	Position on 2L	# of Alleles	Allele Linked to High Oocyst #	Allele Linked to Low Oocyst #	Average # of Oocysts with Susceptible Allele	Average # of Oocysts with Resistant Allele
2L.13808912	13.8 MB	3	87	n.d.	2.92	n.d.
H796	16.7 MB	4	84	82	2.92	0.08
2L.17686894	18.3 MB	4	189	180	2.92	0.08
2L.25C	26.6 MB	4	72	132	2.50	0.09
2L.25A	29 MB	3	n.d.	160	n.d.	0.08

Linkage data for the five microsatellite markers significantly linked with P. falciparum infection outcome (genome-wide p value < 0.05). Physical positions are based on the inverted 2La/a chromosome form. Other markers in this region did not yield significant linkage signal in this pedigree due to a low level of marker informativeness. Because 4 distinct chromosomes were segregating, as indicated by most markers, the two markers with 3 alleles were not fully informative because 1 allele marked 2 chromosomes, thus obscuring the linkage signal from the non-informative cases (labeled n.d., not detected). The nominal and genome-wide p values for all markers listed in the table are 0.002 and 0.040, respectively

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