|  | Nr mice exp 1 | Nr mice exp 2 |
---|
Days | Dose | CWavir | CWvir | CWavir | CWvir |
---|
4 | 0 | 5 | 5* | 4 | 4# |
4 | 1 | 5 | 5** | 4 | 4 |
4 | 3 | 5 | 5 | 4 | 4 |
4 | 5 | 5 | 5§ | 4 | 4 |
 |  |
Nr mice exp 3
| Â | Â |
Days
|
Dose
|
CW
avir
|
CW
vir
| Â | Â |
1 | 0 | 4 | 4 | Â | Â |
1 | 4 | 4 | 4 | Â | Â |
1 | 8 | 4 | 4 | Â | Â |
1 | 12 | 4 | 4 | Â | Â |
1 | 20 | 4 | 4 | Â | Â |
- Days: duration of pyrimethamine treatment in days, starting from day 5 after infection. Dose: mg/kg/day. Nr mice: sample sizes for each group, with sample sizes for each experiment. * Each symbol indicates a mouse excluded from analysis, euthanized early in the experiment because of severe anaemia. § 1 mouse excluded, no parasites detected at time of treatment. # 4 mice euthanized on d11 and d12 after infection, data have been used where possible.