Figure 2
From: Towards optimal design of anti-malarial pharmacokinetic studies
Pharmacokinetic profile of dihydroartemisinin following a single intravenous dose of 120 mg artesunate (Vd = 38 L, CL = 37 L.hr-1). Superimposed on the pharmacokinetic profile is the symbol "o" (Panel A) to represent the sampling times for the rich design in Table 1 (20 patients, 10 samples per patient) and the symbol "O" (Panel B) to represent the sampling times for the sparse design in Table 1 (50 patients, 4 samples per patient).