From: Towards optimal design of anti-malarial pharmacokinetic studies
Number of patients | Number of samples per patient | Sampling times | Expected precisionb of PK parameter estimates (initial valuesc: Vd = 38 L, CL = 37 L.hr-1) | Expected precisionb of inter-patient variability estimates (initial values: ωVd = 0.5, ωCL = 0.5) | Expected precisionb of residual variability estimate (initial value: σε = 200 ng.mL-1) | Efficiencyd (%) |
---|---|---|---|---|---|---|
20 | 10 | {0.25, 0.5, 0.75, 1, 1.5, 2, 2.5, 3, 4, 6} | 11.5, 11.4 | 33.5, 33.1 | 5.6 | 100 (criterion = 13.7) |
40 | 5 | {0.25, 0.75, 1, 2, 4} | 8.2, 8.2 | 24.2, 24.3 | 6.5 | 157 |
50 | 4 | {0.25, 0.75, 2, 4} | 7.4, 7.6 | 21.8, 22.9 | 7.1 | 177 |
10 | 10 | {0.25, 0.5, 0.75, 1, 1.5, 2, 2.5, 3, 4, 6} | 8.8, 8.9 | 25.8, 26.6 | 6.2 | 143 |
25 | 4 | {0.25, 0.75, 2, 4} | Â | Â | Â | Â |