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Table 2 Laboratory monitoring of biological events of ANQ and CQ+SP treatments

From: Artemisinin-naphthoquine combination (ARCO™) therapy for uncomplicated falciparum malaria in adults of Papua New Guinea: A preliminary report on safety and efficacy

Laboratory parameters

Treatments

D0

D3

D7

D14

21

28

Biochemistry

       

Glucose

mm/L

ANQ

4.9 ± 0.9

5.5 ± 1.5

4.8 ± 0.8

4.5 ± 0.8

4.5 ± 0.5

5.0 ± 1.6

 

CQ+SP

5.0 ± 1.0

5.5 ± 1.5

4.9 ± 0.8

4.5 ± 0.8

4.6 ± 0.5

5.2 ± 1.6

Liver function

       

*AST

Units/L

ANQ

43.2 ± 16.4

43.7 ± 22.6

41.6 ± 32.1

35.7 ± 17.9

31.0 ± 10.4

33.4 ± 10.2

 

CQ+SP

44.2 ± 16.4

43.2 ± 16.4

42.2 ± 32.1

35.2 ± 17.9

31.0 ± 10.4

35.4 ± 10.2

**ALT

Units/L

ANQ

44.1 ± 20.9

47.9 ± 24.9

53.0 ± 49.2

57.3 ± 33.7

36.4 ± 14.8

36.3 ± 21.4

 

CQ+SP

46.1 ± 20.9

47.9 ± 24.9

54.0 ± 49.2

57.3 ± 34.0

36.4 ± 14.9

35.3 ± 21.4

Bilirubin

μm/L

ANQ

19.4 ± 14.3

12.1 ± 8.8

10.7 ± 5.0

8.3 ± 1.5

8.8 ± 1.3

8.8 ± 1.9

 

CQ+SP

18.4 ± 14.3

12.1 ± 8.8

10.6 ± 5.0

8.3 ± 1.5

8.0 ± 1.3

8.8 ± 2.0

Alkaline phosphatase

Units/L

ANQ

75.9 ± 18.6

81.8 ± 24.7

87.5 ± 27.5

91.3 ± 29.5

80.5 ± 24.3

95.1 ± 38.1

 

CQ+SP

76.4 ± 20.2

83.4 ± 23.1

86.1 ± 25.2

91.8 ± 28.4

77.6 ± 21.5

84.0 ± 39.0

#GGT

Units/L

ANQ

39.5 ± 22.7

40.3 ± 24.8

34.7 ± 22.3

29.5 ± 13.5

16.8 ± 11.9

22.5 ± 7.4

 

CQ+SP

40.5 ± 22.7

40.3 ± 24.8

34.7 ± 22.3

29.5 ± 13.5

16.3 ± 12.9

22.5 ± 7.5

Renal function

       

Creatinine

μm/L

ANQ

92.7 ± 19.4

91.8 ± 14.2

91.9 ± 18.1

87.9 ± 13.7

85.9 ± 10.9

79.3 ± 17.5

 

CQ+SP

93.3 ± 19.3

92.8 ± 14.4

93.5 ± 19.1

88.9 ± 14.0

85.3 ± 11.5

80.4 ± 18.4

Haematology

       

Haemoglobin

g/dl

ANQ

10.8 ± 2.3

10.6 ± 1.8

10.4 ± 1.2

10.7 ± 1.0

11.1 ± 1.7

11.6 ± 1.4

 

CQ+SP

11.0 ± 2.3

10.7 ± 1.9

10.5 ± 1.3

11.0 ± 0.9

11.1 ± 1.6

11.6 ± 1.5

WBC

×109/L

ANQ

5.2 ± 2.4

5.4 ± 1.7

5.5 ± 1.7

6.5 ± 2.5

6.6 ± 1.6

6.1 ± 1.7

 

CQ+SP

5.4 ± 2.3

5.4 ± 1.6

5.8 ± 1.6

6.5 ± 2.3

6.6 ± 1.7

6.2 ± 1.8

Electrolytes

       

Sodium

mm/L

ANQ

134.9 ± 5.6

138.2 ± 3.4

135.6 ± 7.6

137.2 ± 2.6

136.5 ± 3.1

139.6 ± 5.4

 

CQ+SP

135.9 ± 5.5

138.3 ± 3.3

136.1 ± 7.1

137.2 ± 2.4

136.4 ± 2.9

140.0 ± 5.5

Potassium

mm/L

ANQ

3.8 ± 0.7

4.1 ± 1.1

4.2 ± 0.8

4.1 ± 0.7

3.9 ± 0.3

4.0 ± 0.7

 

CQ+SP

3.8 ± 0.7

4.1 ± 0.7

4.2 ± 0.7

4.0 ± 0.7

4.0 ± 0.7

4.1 ± 1.0

  1. *AST = Aspartate aminotransferase ** ALT = Alanine aminotransferase #GGT = Gamma-glutamyltransferase