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Table 2 Plasma concentrations of amodiaquine and desethylamodiaquine

From: Population pharmacokinetics of artesunate and amodiaquine in African children

 

Median (Range) (N) Concentration (ng/mL)

AS+AQ

AS/AQ

Amodiaquine

  

Pre-dose 1

3.54 (n/a) (1)

1.96 (n/a) (1)

Post-dose 3

15.0 (3.8 – 48.9) (32)

14.1 (5.6 – 54.4) (30)

Desethylamodiaquine

  

Pre-dose 1

7.7 (1.0 – 108.9) (15)

9.3 (1.6 – 137.1) (15)

Post-dose 3

396.6 (86.9 – 1307.8) (32)

347.1 (143.3 – 759.3) (30)

Day-7

73.9 (40.7 – 186.9) (15)

91.5 (31.4 – 235.2) (15)

Day-14

48.8 (11.7 – 84.1) (15)

41.0 (24.1 – 99.2) (16)

Day-21

29.0 (19.2 – 47.3) (10)

17.7 (9.3 – 48.0) (18)

Day-28

17.7 (5.4 – 100.1) (18)

17.4 (5.5 – 69.9) (12)