From: Population pharmacokinetics of artesunate and amodiaquine in African children
Parameter | Estimate (SE) | Inter-subject variation CV% |
---|---|---|
DHA | Â | Â |
Ka (h -1) | 4.271 (2.091) | Â |
CL/F1 (L kg-1 h-1) | 0.636 (0.075) | Â |
Increase in CL/F due to the 3rd dose period | 0.760 (0.160) | Â |
V/F (L kg-1) | 2.285 (0.317) | 47% |
Effect of Age on V/F | 0.063 (0.015) | Â |
T 1/2 (h) | Â | Â |
   1st dose | 2.5 [0.8–4.5]2 |  |
   3rd dose | 1.1 [0.4–2.0]2 |  |
σ (ng/mL) | 340 |  |
Anti-malarial Activity | Â | Â |
Ka (h-1) | 4.744 (2.587) | Â |
CL/F1 (L kg-1 h-1) | 0.616 (0.071) | Â |
Increase in CL/F due to the 3rd dose period | 0.662 (0.150) | Â |
V/F (L kg-1) | 2.134 (0.287) | 48% |
Effect of Age on V/F | 0.063 (0.013) | Â |
T 1/2 (h) | Â | Â |
   1st dose | 2.4 [0.5–5.7]2 |  |
   3rd dose | 1.2 [0.2–2.7]2 |  |
σ (ng/mL) | 353 |  |