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Table 1 Censoring events by drug category for the efficacy analysis (both comparative and non-comparative studies included)

From: Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysis

   AS&AQ Other ACTs non-ACT
Criteria   n % n % n %
Total   5987 100% 2787 100% 2926 100%
Censored on Day 0 - no drug intake    3    
  - voluntary withdrawal 19      
  - self-medication 10     16  
  - protocol violation 16   18    13
Sub-total   5942 99% 2769 99% 2897 99%
Failure Total recurrent cases 1126 91% 429 95% 1171 95%
     - PCR confirmed* 203   95   436  
     - indeterminate* 47   47    
     - no PCR/no sample* 20   51   34  
  Danger sign/severe malaria/death* 24 2% 8 2% 1 <1%
  Increased parasitaemia or >25% Day3*      45 3%
  Clinician decision* 1 <1%     
  Drug vomiting 44 4% 6 1%   <1%
  Still positive when lost to follow-up* 29 2% 5 1% 13 1%
  Lost result* 11 1% 3 1% 8 1%
  Total 1235 100% 451 100% 1238 100%
  1. * Classified as recrudescent failure
  2. ACT: artemisinin combination therapy.