Table 1 Censoring events by drug category for the efficacy analysis (both comparative and non-comparative studies included)
| Â | Â | AS&AQ | Other ACTs | non-ACT | |||
|---|---|---|---|---|---|---|---|
Criteria | Â | n | % | n | % | n | % |
Total | Â | 5987 | 100% | 2787 | 100% | 2926 | 100% |
Censored on Day 0 | - no drug intake | Â | Â | 3 | Â | Â | Â |
| Â | - voluntary withdrawal | 19 | Â | Â | Â | Â | Â |
| Â | - self-medication | 10 | Â | Â | Â | 16 | Â |
| Â | - protocol violation | 16 | Â | 18 | Â | Â | 13 |
Sub-total | Â | 5942 | 99% | 2769 | 99% | 2897 | 99% |
Failure | Total recurrent cases | 1126 | 91% | 429 | 95% | 1171 | 95% |
|  |    - PCR confirmed* | 203 |  | 95 |  | 436 |  |
|  |    - indeterminate* | 47 |  | 47 |  |  |  |
|  |    - no PCR/no sample* | 20 |  | 51 |  | 34 |  |
| Â | Danger sign/severe malaria/death* | 24 | 2% | 8 | 2% | 1 | <1% |
| Â | Increased parasitaemia or >25% Day3* | Â | Â | Â | Â | 45 | 3% |
| Â | Clinician decision* | 1 | <1% | Â | Â | Â | Â |
| Â | Drug vomiting | 44 | 4% | 6 | 1% | Â | <1% |
| Â | Still positive when lost to follow-up* | 29 | 2% | 5 | 1% | 13 | 1% |
| Â | Lost result* | 11 | 1% | 3 | 1% | 8 | 1% |
| Â | Total | 1235 | 100% | 451 | 100% | 1238 | 100% |