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Table 3 Summary of the Day-28 ACPR rates and difference (95% confidence intervals), the data is not PCR corrected.

From: Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi

Day-28 Outcome

ACPR Rate

ACPR Difference (95% Confidence Intervals)

P value

ITT (missing = failure)

CPD (n = 422)

63.7%

  

AL (n = 209)

85.2%

  

SP (n = 210)

50.0%

  

CPD vs SP

 

13.7%

(5.6%, 21.9%)

0.001

AL vs CPD

 

21.4%

(14.8%, 28.1%)

< 0.001

AL vs SP

 

35.2%

(26.9%, 43.5%)

< 0.001

ITT (missing = success)

CPD (n = 422)

79.4%

  

AL (n = 209)

98.6%

  

SP (n = 210)

70.5%

  

CPD vs SP

 

9.4%

(2.1%, 16.7%)

0.01

AL vs CPD

 

19.2%

(15.0%, 23.4%)

< 0.001

AL vs SP

 

28.6%

(22.2%, 35.0%)

< 0.001

Per Protocol

CPD (n = 356)

75.6%

  

AL (n = 181)

98.3%

  

SP (n = 168)

62.5%

  

CPD vs SP

 

13.1%

(4.5%, 21.6%)

0.003

AL vs CPD

 

22.8%

(17.9%, 27.6%)

< 0.001

AL vs SP

 

35.8%

(28.3%, 43.4%)

< 0.001