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Table 6 Chi-square Hardy-Weinberg equilibrium tests for SNP data acquired by sequencing.

From: A microarray-based system for the simultaneous analysis of single nucleotide polymorphisms in human genes involved in the metabolism of anti-malarial drugs

 

Cambodia

Tanzania

SNP

χ 2

P

χ 2

P

CYP2A6*2

N.A.

 

N.A.

 

CYP2B6*5

10.86

< 0.01

N.A.

 

CYP2B6*6

0.28

0.60

1.81

0.18

CYP2C8*3

N.A.

 

N.A.

 

CYP2C9*3

2.94

0.08

N.A.

 

CYP2C9*5

N.A.

 

0.14

0.71

CYP2C19*3

N.A.

 

N.A.

 

CYP2D6*4

N.A.

 

15.75

< 0.01

CYP2D6*10 (100C>T)

1.39

0.24

1.34

0.25

CYP2D6*10 (4180G>C)

2.01

0.16

1.24

0.27

CYP2D6*17 (1023C>T)

N.A.

 

0.05

0.82

CYP2D6*17 (2850C>T)

0.24

0.62

4.94

0.03

CYP3A4*1B

0.10

0.75

0.04

0.84

CYP3A5*3

0.64

0.42

0.04

0.84

N.A.T2*5

0.10

0.75

0.01

0.92

N.A.T2*6

0.48

0.49

1.07

0.30

N.A.T2*7

0.01

0.92

0.14

0.71

N.A.T2*14

N.A.

 

5.02

0.03

  1. χ2 indicates the result from the Hardy-Weinberg equilibrium test, P the one-tailed P-value, and N.A. that Chi-square could not be calculated because the allele frequency was either 0% or 100%.