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Table 5 Association between IL4-590 genotype and anti-P. falciparum -IgG1, -IgG2, -IgG3 and IgE low or high tiled levels in patients with complicated and uncomplicated malaria.

From: IL4 gene polymorphism and previous malaria experiences manipulate anti-Plasmodium falciparum antibody isotype profiles in complicated and uncomplicated malaria

    

Complicated

 

Uncomplicated

 

3-tiles of Ig levels

N

CC

CT

TT

P -value#

CC

CT

TT

P -value#

Anti-Pf IgG1

  

274

5A

46B

53C

 

11A

67B

84C

 

Anti-Pf IgG2

  

274

5

46

53

 

11

68

83

 

Anti-Pf IgG3

  

276

5

46

53

 

11

68

85

 

Anti-Pf IgE

  

277

5

47

53

 

11

68

85

 

Anti-Pf IgG1*

Low

0-14.47

91D

0

20

26

0.395

2

23

16

0.118

 

Medium

14.76-106.1

92

2

16

16

 

3

20

32

 
 

High

107.2-1874

91

3

10

11

 

6

24

36

 

Anti-Pf IgG2*

Low

0.414-2.384

91

0

26

23

0.856

2

23

17

0.179

 

Medium

2.386-6.617

92

3

12

22

 

3

19

29

 
 

High

6.629-177

91

2

8

8

 

6

26

37

 

Anti-Pf IgG3*

Low

0.053-0.798

92

1

19

30

0.0054

3

20

16

0.079

 

Medium

0.854-3.55

92

2

13

18

 

5

22

28

 
 

High

3.629-119

92

2

14

5

 

3

26

41

 

Anti-Pf IgE**

Low

0.015-0.3851

92

2

15

17

0.896

3

28

25

0.564

 

Medium

0.3854-1.332

93

2

17

21

 

4

14

30

 
 

High

1.346-29.05

92

1

15

15

 

4

26

30

 
  1. N = Number of plasma for determining IgG1, IgG2, IgG3, IgE and genotyping IL4-590, # = Chi-squared test was used to test the difference of IL4-590 CC+CT and TT distribution between the low and high 3 tiles. * = μg/ml, ** = ng/ml, A = number of patients who carry IL4-590 CC genotype, B = number of patients who carry IL4-590 CT genotype, C = number of patients who carry IL4-590 TT genotype, D = Number of patients who had low, middle and high anti-P. falciparum -IgG1, -IgG2, -IgG3 and IgE levels.