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Table 6 Association between IL4-590 genotype and anti-P. falciparum -IgG1 and -IgG3 levels base on previous experiences malaria infection in patients with complicated and uncomplicated malaria.

From: IL4 gene polymorphism and previous malaria experiences manipulate anti-Plasmodium falciparum antibody isotype profiles in complicated and uncomplicated malaria

   

Complicated malaria

   

Without previous malaria experiences (76) a

With previous malaria experiences (27)

 

3-tiles of Ig levels

CC

CT

TT

P -value #

CC

CT

TT

P -value #

Anti-Pf IgG1*

Low

0-14.47

0A

17B

21C

0.1373

0

3

4

0.7715

 

Medium

14.76-106.1

1

11

11

 

1

4

5

 
 

High

107.2-1874

2

5

6

 

1

4

5

 

Anti-Pf IgG3*

Low

0.053-0.798

0

17

23

0.2136

1

2

6

0.0156

 

Medium

0.854-3.55

2

10

11

 

0

2

7

 
 

High

3.629-119

1

6

4

 

1

7

1

 
   

Uncomplicated malaria

   

Without previous malaria experiences (74)

With previous malaria experiences (91)

   

CC

CT

TT

P -value #

CC

CT

TT

P -value #

Anti-Pf IgG1

Low

0-14.47

0

15

11

0.8019

2

7

5

0.1219

 

Medium

14.76-106.1

2

9

12

 

1

11

20

 
 

High

107.2-1874

2

11

11

 

4

13

25

 

Anti-Pf IgG3

Low

0.053-0.798

1

13

12

0.8772

2

7

4

0.0206

 

Medium

0.854-3.55

1

10

12

 

4

11

16

 
 

High

3.629-119

2

12

11

 

1

14

30

 
  1. a = Number of patients (in the parenthesis), # = Chi- squared test was used to test the difference of IL4-590 CC, CT and TT distribution between the low and high 3 tiles, * = μg/ml, A, B and C = number of patients with previous malaria experiences for determining anti-P. falciparum -IgG1, -IgG3 and carry IL4-590 CC, CT, TT genotypes, respectively.