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Table 7 Trends in chloroquine sensitivity profiles during periods of co-administration of antihistamines with chloroquine or use of sub-therapeutic dosage regimen in patients from a private hospital in Ibadan, south-west Nigeria

From: Potential contribution of prescription practices to the emergence and spread of chloroquine resistance in south-west Nigeria: caution in the use of artemisinin combination therapy

Year

Frequency of co-administration of antihistamine

Frequency of prescription of Full course regimen

Frequency of sub-therapeutic regimen

Reported chloroquine sensitivity

1983 (N = 289)

74.7%

93.1%

6.9%

100% [19, 20]

1985 (N = 298)

80.0%

98.3%

1.7%

 

1987 (N = 295)

84.4%

96.3%

3.7%

100% [21]

1989 (N = 220)

72.3%

97.3%

2.7%

 

1992 (N = 258)

67.4%

78.3%

21.7%

85% [22]

1995 (N = 243)

48.6%

72.8%

27.2%

 

1997 (N = 241)

51.9%

56.4%

43.6%

<40%([3]