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Table 3 Relative frequencies of polymorphic Pfdhps gene SNPs according to villages, ages and years

From: Field-based evidence of fast and global increase of Plasmodium falciparum drug-resistance by DNA-microarrays and PCR/RFLP in Niger

 

Number of samples

Overall

Banizoumbou vs Zindarou

Adults vs under 15

2003 vs 2006

pfdhpsSer436Phe

84

71.4%

73.8% vs 69.0%

(p = 0.629)

52.9% vs 76.1%

(p = 0.059)

76.2% vs 66.7%

(p = 0.334)

pfdhpsAla437Gly

49

73.4%

71.0% vs 77.8%

(p = 0.743)

50.0% vs 79.5%

(p = 0.06)

77.3% vs 70.4%

(p = 0.586)

pfdhpsAla581Gly

79

10.1%

19.0% vs 0.0%

(p = 0.006)*

12.5% vs 9.5%

(p = 0.661)

0.0% vs 20.5%

(p = 0.002)*

pfdhpsAla640Thr

90

97.8%

95.6% vs 100.0%

(p = 0.494)

100.0% vs 97.1%

(p = 1.0)

100.0% vs 95.5%

(p = 0.236)

436, 437

49

61.2%

61.3% vs 61.1%

(p = 0.99)

30.0% vs 69.2%

(p = 0.033)

68.2% vs 55.6%

(p = 0.367)

436, 437, 581

48

10.4%

16.1% vs 0.0%

(p = 0.146)

10.0% vs 10.5%

(p = 1.0)

0.0% vs 19.2%

(p = 0.054)

436, 437, 640

48

58.3%

56.7% vs 61.1%

(p = 0.762)

30.0% vs 65.8%

(p = 0.07)*

50.0% vs 68.2%

(p = 0.203)

436, 437,581, 640

47

10.6%

16.7% vs 0.0%

(p = 0.143)

10.0% vs 10.8%

(p = 1.0)

0.0% vs 20.0%

(p = 0.052)

  1. in bold p < 0.05
  2. * link kept in logistical regression model