Figure 7

Average parasitemias (A) and survival (B) of C57BL/6 mice infected with recrudescent PbAus, or PbAus, and administered artemisone twice a day, on days 7-9 post-inoculation. Recrudescent parasites were isolated from peripheral blood of C57Bl/6 mice previously treated with 2 × 5 mg/kg/d artemisone, and were injected to naïve mice. After an additional passage, the recrudescent parasites were injected to C57Bl/6 mice, and artemisone administered at 2 × 2.5 mg/kg/d. Two additional groups of mice were infected with non-recrudescent PbAus and similarly treated. No significant differences were seen in either parasitemias or survival when comparing control PbAus- and recrudescent PbAus-infected mice. Differences in parasitemias between control and treated groups were significant (p < 0.001), as were the differences in survival rates. Average values ± SD (error bars) are presented. Arrows represent injections.