Table 2 Data relating to post-treatment clinical and parasitological response
Variable | P. knowlesi(n = 33) | P. vivax(n = 23) | P value |
|---|---|---|---|
Admission parasite count (geometric mean per microlitre) | 3724 (1,845-7480) | 4650 (2,752-7785) | 0.6 |
Fever clearance time (hours) | 26.5 [16-34] | 20.8 [12-32] | 0.32 |
Percentage given paracetamol during hospital stay | 79 | 52 | 0.05 |
Hours before fever clearance | 6 [2-13] | 4 [1-12] | 0.48 |
Time to clear 50% of admission parasite count (hours) | 3.1 (2.84-3.43) | 6.3 (5.3-7.8) | 0.02 |
Time to clear 90% of admission parasite count (hours) | 10.3 (9.4-11.4) | 20.9 (17.6-25.9) | 0.02 |
Calculated time to parasite count < 5 per microlitre (hours) | 35.8 [30.8-51.2] | 62.1 [43.0-80.2] | < 0.01 |
Parasite reduction ratio at 24 hours | 99.3 [50-100] | 95.9 [58-100] | < 0.01 |
Percentage negative at 24 hours | 33 (16-31) | 4.6 (0-14) | Â |
Parasite stages (%, range) | Â | Â | Â |
Immature trophozoites | 49.5 (3.1-100) | 64.4 (2.7-98.9) | 0.06 |
Pigmented trophozoites | 41.5 (0-88.4) | 28.4 (19.1-37.6) | 0.09 |
Schizonts | 4.0 (0-38.6) | 1.9 (0-36.3) | < 0.01 |
Gametocytes | 5.6 (0-32.8) | 7.1 (0-53.7) | 0.15 |
Slope of curve for natural logarithm parasite count | Â | Â | Â |
All | 0.223 ± 0.02 | 0.110 ± 0.02 | 0.02 |
Immature trophozoites | 0.182 ± 0.02 | 0.127 ± 0.03 | NT |
Mature trophozoites | 0.269 ± 0.02 | 0.147 ± 0.03 | NT |
Schizont | 0.191 ± 0.02 | 0.02 ± 0.02 | NT |
Gametocyte | 0.061 ± 0.01 | 0.012 ± 0.03 | NT |