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Table 1 Enrollment characteristics of children with uncomplicated malaria (ITT)

From: An open randomized clinical trial in comparing two artesunate-based combination treatments on Plasmodium falciparum malaria in Nigerian children: artesunate/sulphamethoxypyrazine/pyrimethamine (fixed dose over 24 hours) versus artesunate/amodiaquine (fixed dose over 48 hours)

Characteristics

AS + SMP

(n = 250)

AS + AQ

(n = 250)

p-value

Sex (M:F)

128:122

136:114

0.299

Age (months)

   

Mean ± SD

61.88 ± 38.139

60.77 ± 35.93

0.739

Range

12 - 156

12 - 156

 

Proportion

   

With age < 5 years

49.2%

58.8%

0.031

Weight

   

Mean ± SD

17.51 ± 7.01

17.29 ±6.90

0.729

Range

6 - 40

7 - 40

 

Temperature (Day 0)

   

Mean ± SD

37.91 ± 1.15

37.83 ± 1.17

0.441

Range

35.5 - 40.5

35.3 - 40.7

 

Parasite Density (Day 0)

   

Median

15549.00

11673.50

0.078

Range

2009 - 199950

2020 - 199200

 

PCV* (Day 0)

   

Mean ± SD

29.79 ± 5.18

29.94 ± 5.09

0.748

Range

12 - 42

12 - 41

 

AST* (Day 0)

   

Mean ± SD

38.76 ± 14.66

38.88 ± 15.54

0.929

Range

10 - 95

10 - 101

 

ALT* (Day 0)

   

Mean ± SD

31.10 ± 16.63

30.27 ± 15.29

0.559

Range

10 - 99

10 - 91

 

CRT* (Day 0)

   

Mean ± SD

0.56 ± 0.26

0.56 ± 0.24

0.860

Range

0.20 - 1.30

0.20 - 1.20

 

Total Bilirubin (Day 0)

   

Mean ± SD

0.58 ± 0.28

0.62 ± 0.27

0.191

Range

0.10 - 1.70

0.10 - 1.30

 

WBC (Day 0)

   

Median

7450.00

7500.00

0.735

Range

1200 - 38000

1300 - 24600

 
  1. PCV = packed cell volume; AST = aspartate aminotransferase; ALT = alanine aminotransferase; CRT = creatinine