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Figure 1 | Malaria Journal

Figure 1

From: Schistosoma mansoni infection reduces the incidence of murine cerebral malaria

Figure 1

Brain histology of non-infected and PbA-infected ICR mice. Brains were removed from control non-infected mice (n = 10) or PbA-infected moribund mice (n = 10) on day 8 post- PbA inoculation. Representative sections are shown for each group. (A) Representative section of the cortex of a control mouse, demonstrating lack of vessel distention or pathology (magnification 20×). (B) Representative section of the submeningeal cortex of a control mouse, demonstrating the lack of haemorrhages or cellular infiltrations (magnification 10×). (C) Mononuclear cell aggregation in a meningeal vessel, increased cellularity, and piknotic nuclei in a prostrate mouse (magnification 20×). (D) Distended thallamic blood vessel; mononuclear cell interacting with activated endothelial cells (boxed) in a prostrate mouse (magnification 40×). (E) "Spongy" tissue - evidence of edema in a PbA-infected mouse suffering from coma (magnification 40×). (F) Meningeal haemorrahges in a PbA-infected mouse suffering from coma (magnification 10×).

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