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Table 1 Physiochemical properties of the 4-position library

From: Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols

Parameter*

Range

MW

335-552

LogD

-1.2-6.9

PSA

36-111

LogP

-2.2-7.1

FRBs

3-12

HBDs

1-5

HBAs

3-8

LVs

0-1

  1. * MW is molecular weight, PSA = polar surface area, FRBs = freely rotatable bonds, HBDs = H-bond donors, HBAs = H bond acceptors and LVs = Lipinski violations.
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Malaria Journal

ISSN: 1475-2875

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