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Table 5 Proportions of different functional groups present in active and inactive amines

From: Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols

Chemical Property

Number of Analogs in Subset of Active or Inactive Amines*

P value**

 

Active (# of 69) (%)

Inactive (# of 129) (%)

 

N or OH Replacement

1 (1.4)

12 (9.3)

0.036

Conjugated Amines

9 (13)

49 (38)

0.0003

Benzyl Amines

15 (22)

19 (15)

0.238

Side-chain Contains Heteroatoms

36 (52)

96 (74)

0.0025

Tertiary Amines

20 (29)

31 (24)

0.4964

Secondary Amines

49 (71)

78 (60)

0.0129

All Carbon Side-chain

21 (30)

8 (6.2)

< 0.0001

  1. * An active compounds is one with an IC90 < 1000 nM against Pf C2A. ** Fisher's exact, P < 0.05 considered significant.