From: Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols
Chemical Property | Number of Analogs in Subset of Active or Inactive Amines* | P value** | |
---|---|---|---|
 | Active (# of 69) (%) | Inactive (# of 129) (%) |  |
N or OH Replacement | 1 (1.4) | 12 (9.3) | 0.036 |
Conjugated Amines | 9 (13) | 49 (38) | 0.0003 |
Benzyl Amines | 15 (22) | 19 (15) | 0.238 |
Side-chain Contains Heteroatoms | 36 (52) | 96 (74) | 0.0025 |
Tertiary Amines | 20 (29) | 31 (24) | 0.4964 |
Secondary Amines | 49 (71) | 78 (60) | 0.0129 |
All Carbon Side-chain | 21 (30) | 8 (6.2) | < 0.0001 |