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Table 2 Outcome of intent-to-treat and per-protocol analyses on day 28 with PCR distinction between recrudescence and reinfection.

From: Efficacy of non-artemisinin- and artemisinin-based combination therapies for uncomplicated falciparum malaria in Cameroon

Comparator1 Treatment PCR-uncorrected outcome PCR-corrected outcom
OR (ITT) OR (PP) OR (ITT) OR (PP)
AS-AQ AQ 0.71
(0.31-1.60)
0.70
(0.26-1.85)
1.24
(0.43-3.56)
3.85
(0.41-35.6)
AS-AQ AS-SP 0.60
(0.23-1.31)
0.55
(0.20-1.53)
0.98
(0.32-3.00)
2.94
(0.30-29.2)
AQ-SP AS-MQ 0.68
(0.26-1.75)
0.13
(0.01-1.10)
1.62
(0.50-5.24)
-
-
AS-AQ AM-LM 0.26
(0.07-1.03)
0.36
(0.06-1.92)
0.13
(0.01-1.10)
0.12
(0-2.04)
AS-CD AS-SP 0.30*
(0.13-0.62)
0.24*
(0.09-0.65)
0.39*
(0.17-0.85)
0.37
(0.12-1.20)
AS-AQ DH-PP 0.32*
(0.12-0.80)
0.12*
(0.02-0.52)
0.61
(0.22-1.66)
0.28
(0.05-1.36)
  1. Treatment outcome on day 28 for studies conducted in 2005-2007. OR (ITT), odds ratio in the case of the intention-to-treat (ITT) analysis, where the total number of patients enrolled was considered. OR (PP), odds ratio in the per-protocol (PP) analysis.
  2. 1Treatment taken as reference. Odds-ratios (OR, 95% confidence intervals in parentheses) were calculated for the pairs of ACT in each randomized study, except for the study in 2005 (AS-AQ vs AQ). Asterisks denote P < 0.05.